Canada,Pharmacy,Reports,Cell,T health Canada Pharmacy Reports Cell Transplant as a New Nerve Pain
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Aside from generic Neurontin, which affectschemicals and nerves in the body that are involved in the cause of seizures andsome types of pain, a new study in mice suggests that scientists may someday beable to treat nerve pain by transplanting embryonic nerve cells to restore abroken nervous system. "Nothing that gets rid ofthe pain works for a long period of time," said study co-author AllanBasbaum, chair of the department of anatomy at the University of California,San Francisco. "The problem is that even if drugs sort of work, they workeverywhere in the body and inevitably have adverse side effects like sedationand mental clouding." "Nerve pain can strike avariety of types of patients, from those who have had shingles or undergonechemotherapy to those with diabetes. Scientists think certain nerve cellsbecome damaged or lost, and lose the ability to regulate the pain signals thatgo to the brain," Basbaum said. "Some of the cellsdeveloped into neurons. Within four weeks, the mice lost theirhypersensitivity." Basbaum said, "The findings show unequivocallythat the cells integrated into the nervous system of the mice." If this isfound feasible in humans, to buyNeurontin will no longer be an option. "The next step is toinject human embryonic nerve cells into mice that are genetically engineered tonot reject human tissue. We want to do the groundwork to learn how to handlehuman cells," Basbaum said. "The ultimate goal is totest the treatment in humans," Basbaum said. "But if the cells don'tintegrate as they do in the mouse, or the cells don't survive, then it doesn'twork." He said, "the potentialcost of the procedure isn't known. Any work with human embryonic cells couldcreate controversy because they're derived from human embryos. However,scientists are trying to find alternative ways to develop the cells." Laura Stone, an assistantprofessor at McGill University's Alan Edwards Center for Research on Pain inMontreal, praised the study. "The researchdemonstrates that transplantation of cells into the spinal cord could be usedas a strategy perhaps not only in chronic pain but in spinal cord injury orother neurodegenerative disorders," she said. "Still, the treatmentthat worked in mice might not work in humans. Even if it does, an availabletreatment for people would be many, many years away," Stone added. "In the big picture,however, there has been an enormous amount of progress in the last 20 years onunderstanding basic mechanisms underlying chronic pain in general andneuropathic pain in particular," Stone said. "We as a field haveidentified many new possible drug targets that were unknown just a few yearsago." Canada pharmacy willcontinue to maintain their established dedication in carrying out missions toprogress in the health arena. A nerve is any of the filamentous bands of nervous tissuethat connect parts of the peripheral nervous system with other organs. It ismade up of axons and dendrites which have protective and supportive structures.A nerve provides a common pathway for the electrochemical nerve impulses thatare transmitted along each of the axons. It is made up of axons and dendriteswhich have protective and supportive structures. A nerve provides a commonpathway for the electrochemical nerve impulses that are transmitted along eachof the axons.
Canada,Pharmacy,Reports,Cell,T