Capsaicin,has,role,promoting,b health Capsaicin has a role on promoting brain tumor cell death
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NPC is a kind of cells present in children's brain, can be used tofight tumors, can secrete substances induced cancer cell death.The scientists determined these secretesubstances is capsaicin, and clarify the mechanism of capsaicin protects thebrain from the tumor against. The capsaicin signaled by the capsaicin receptorTRPV1, TRPV1 is highly expressed in malignant glioma brain cancer, capsaicin discretesampling and activate the cancer cells in a strengthen pathways to promotecancer cell death, however, in the no tumor brain, the level of TRPV1expression is low. Capsaicin is the active ingredient in chili, have irritatingand burning sensation in the oral cavity of mammal. Capsaicin and some compoundsassociated and referred to as peppers, they are secondary metabolites producedby the pepper, pure capsaicin is a water-repellent lipophilic, colorless,odorless, crystalline or waxy compound.Capsaicin in the treatment of adult mousebrain tumor, can reflect this young NPCs tumor inhibition. Grown inintracranial tumors are known as brain tumors, including primary brain tumorfrom the brain parenchyma and transferred from other parts of the body to thebrain secondary brain tumor. In recent years, the incidence of intracranialtumors show upward trend. According to statistics, the intracranial tumoraccounts for about 5% of the whole-body tumor, accounting for 70% of childhoodtumors, and other malignancies ultimately will be 20-30% turn into theintracranial.The study reveals a potentially powerfuluse of endogenous tumor of the brain molecules inhibit, the inhibitiondependent on a large number of NPC, or have significance for the treatment ofpatients in different age. In addition, the discovery of the capsaicin receptorTRPV1 passed signal can be as a candidate drug target pathway for brain tumors.About the tumor suppressor role of capsaicin has long been understood byscientists, and tireless research on the mechanism. In 2007, Britishresearchers suggested that the key mechanism of capsaicin tumor suppressor is attackingthe mitochondria of cancer cells.Mitochondria is the energy factories ofcells, capsaicin attacks the mitochondria of cancer cells cause the cancercells to apoptosis. Researchers object to cultured cells of lung cancer, andpancreatic cancer, found that capsaicin attack tumor cells without harminghealthy cells. This is because there is a great difference of the mitochondrialbiochemical characteristics of the tumor cells and normal cells.According to capsaicinsupplier, capsaicin is very easy to get in the daily diet, so theresults of this study seems to demonstrate eating such as chili foods is notonly safe, but also have the effect of preventing cancer. In addition,capsaicin has been used as pharmaceutical raw materials of drugs intreating psoriasis and other skin disease, the scientists hope that throughfurther research and demonstration, capsaicin can be developed into anticancerdrugs.Source:http://www.cospcn.com
Capsaicin,has,role,promoting,b