Medication,used,treating,acne, health Medication used in treating acne
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In the past 20 years, these drugs have been widelyused in a variety of skin treatments. Currently, vitamin A acid drugs can bedivided into three generations, first generation is non-aromatic vitamin A acid;second generation is single aromatic vitamin A acid; third generation is multi-aromatic vitamin A acid. Wherein the oral medication for the treatment of acneis mainly the first generation vitamin A acid, the other vitamin A acid areused as cosmetic rawmaterial.The pathwayof first generation vitamin A acid curing acne are mainly have four aspects:` Vitamin A acid can extend basal cell maturation process, and reducethe number of sebaceous glands, sebum synthesis is also reduced, thereby reducingsebum secretion. a Vitamin A acid by regulating the divisionand update of epidermal cells, inhibit epidermal keratinocytes, so that playthe role of opening up pore blockage. bVitamin Aacid can change the lipid composition within sebaceousgland, inhibit the acnes propionibacterium which depends on the lipid environmentto grow, so as to achieve the purpose of anti-inflammatory. c significantly reduce the non-specific inflammation. In summary, vitaminA acid drugs can act on all aspects of acne treatment, maximize to reach the purposeof clearing acne. But according to tretinoin manufacturer,the vitamin A acid drugs have teratogenic effect, can cause elevated bloodlipids, thus banned in pregnant women or those women who plan to becomepregnant within a year. Severe high cholesterol and abnormal liver function patientsshould also avoid using it. Meanwhile, during the treatment will have significantlydry mouth, dry eyes and dry skin feelings, in the succedaneum of vitamin A aciddrugs, isotretinoin is a representative.Fromthe pharmacological perspective, the main reason to cause acne is mainly infour aspects: ` hair follicle infundibulumepithelial cells keratinized; a Propionibacterium acnes masspropagation; b sebum large secretion; c patient's inflammatory response. Because of isotretinoin has suppressionand treatment effect on these four aspects, so the isotretinoin can radicallytreat acne. In these oral drugs which used in treating acne, only isotretinoin canreduce the recurrence of acne.Usingthose drugs in treating acne should be noted that because isotretinoin belongs vitaminA acid drugs, so it should avoid using with vitamin A in order to avoid body'sexcessive vitamin A, cause vitamin A excessive symptoms. In addition, theprocess of taking isotretinoin should avoid using tetracycline antibiotic, soas not to cause intracranial pressure increased, resulting in the so-calledpseudotumor cerebri phenomenon. People with liver and kidney dysfunction shouldnot take it. Most importantly, because all the vitamin A acid drugs can affectfetal development, so that after taking this drug needs contraception, but thetime of different tretinonin discharged from the body is different, thus the requiringcontraception period is not the same. Isotretinoin requires the shortestcontraceptive time in all the oral Vitamin A acid drugs, after stopping meditationonly need three months contraceptive time. While others tretinoin, such as viaminaterequires contracepting six months.Theincidence of acne has a variety of factors, of which the bacterial infection hasplayed a role in disease occurrence and development. For example, the mostisolated from acne vulgaris patients papules, pustules and acne is anaerobicbacteria, including Propionibacterium acnes and Propionibacterium acnesparticles; aerobic bacteria including Staphylococcus aureus, middletype Staphylococcusaureus and Staphylococcus epidermidis, Propionibacterium acnes which is mostcommon. In the acne, the Propionibacterium acnes and Staphylococcus epidermidisincreased significantly, while in pustules, Staphylococcus aureus is the most.Source:http://www.cosprm.com Article Tags: Treating Acne, Acid Drugs, First Generation, Avoid Using, Propionibacterium Acnes, Staphylococcus Aureus
Medication,used,treating,acne,